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Mapping the kinks in faulty DNA

Researchers study DNA changes in yeast. Credit: Alonso Nichols Here is a challenge for you: copy letter-by-letter, word-for-word a document that is 1,200,000 pages long—that’s a stack of paper higher than the Statue of Liberty. And don’t make any typos  or miss any punctuation. Are you up to the task? Yes, you are: your body […]

The curious tale of the cancer ‘parasite’ that sailed the seas

CTVT infection involves the direct transfer of CTVT cancer cells (shown) between dogs by physical contact. Credit: Olga Glebova A contagious canine cancer that conquered the world by spreading between dogs during mating likely arose around 6,000 years ago in Asia and spread around the globe through maritime activities, scientists say. A detailed genetic study, […]

New protein-sensing mechanism discovered

Ribosome binding of NAC is mediated by a ribosome binding regulatory arm (N-αNAC, blue) and a translation sensor domain (N-βNAC, green). N-βNAC senses short nascent chains already deep inside the ribosomal tunnel close to the peptidyl-transferase centre (orange) where amino acids are assembled into proteins. The tunnel-sensing activity of NAC is believed to orchestrate general […]

Joint forces of polarity and cell mechanics

A digitally processed micrograph of mouse skin and hair follicles, with DNA damage (green) in the skin epithelium, including the hair follicle stem cells (purple). Blue depicts cell nuclei. Credit: Martim Dias Gomes The cell polarity protein Par3 controls mechanical changes in the skin and plays an important role in cell division. Malfunction can lead […]

Gatekeepers of the genome

2; n = 2 for each condition). (C) Average expression levels of selected marker genes for pluripotent, mesoderm and endoderm cells in the in vitro differentiated ESCs (TPM – Transcripts Per Kilobase Million; n = 2 for each condition). Nucleic Acids Research (2019). DOI: 10.1093/nar/gkz627″/> An in vitro differentiation system modelling early endoderm differentiation. (A) […]

Research identifies the SIGN-R1 molecule responsible for influenza virus recognition

Electron microscopy of influenza virus. Credit: CDC A team of researchers from the Institute for Research in Biomedicine (IRB, affiliated to USI Università della Svizzera italiana, Switzerland) have discovered and identified a molecule—SIGN-R1—capable of recognizing the multiple variants of influenza and consequently ‘directing’ the immune response in individuals affected by the disease. The results of […]